What is Treg?

Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a critical role in preventing autoimmunity.

What is a CD8+?

CD8+ cells are cytotoxic cells that induce apoptosis in cells, which presents the cognate antigen on MHC class I. Although crucial for responses against intracellular viruses and bacteria, the role of CD8+ T cells in atherosclerosis is controversial.

What is CD4+ and CD8+?

Abstract. CD8+ and CD4+ T lymphocytes have different and complimentary roles: CD8+ (cytotoxic) T cells directly kill cells presenting non-self epitopes while CD4+ (helper) T cells regulate the immune response to a particular antigen.

What do effector CD8 cells do?

CD8 T cells are predominantly killer T cells that recognize pathogen-derived peptides bound to MHC class I molecules. They release perforin (which creates holes (more…) All three classes of effector T cell express one or more members of the TNF family upon recognizing their specific antigen on the target cell.

What is the phenotypic analysis of CD4 + Treg?

Phenotypic Analysis of CD4+ Treg, CD8+ Treg, and Breg Cells in Adult Common Variable Immunodeficiency Patients Altered regulatory lymphocytes may play a role in the pathogenesis and autoimmunity and inflammation associated with CVID.

How are CD8 + Treg lymphocytes an inhibitory agent?

It is currently known that CD8 + Treg lymphocytes have an inhibitory effect through soluble factors or cell-cell contact. In murine and human models, different works have described a number of regulatory mechanisms mediated by CD8 + Treg lymphocytes: (a) direct death of target cell [ 5

Are there CD4 + Treg cells in CVID patients?

CD4+ Treg cell abnormalities have been reported in CVID; however, CD8+ Treg cells have not been reported in CVID. The objective of this study was to evaluate CD4+ Treg and CD8+ Treg cells in CVID patients.

Which is a memory like subset of CD8 + Tregs?

Another ‘memory-like’ regulatory subset, CD8 + Tregs, evaluated as CD8 + CD25 + FOXP3 +, has recently raised interest for their effective suppressive activity.