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What is the principle of microarray?

What is the principle of microarray?

The principle behind microarrays is that complementary sequences will bind to each other. The unknown DNA molecules are cut into fragments by restriction endonucleases; fluorescent markers are attached to these DNA fragments. These are then allowed to react with probes of the DNA chip.

What is a microarray used for?

A microarray is a laboratory tool used to detect the expression of thousands of genes at the same time. DNA microarrays are microscope slides that are printed with thousands of tiny spots in defined positions, with each spot containing a known DNA sequence or gene.

What are the types of microarray?

There are four different types of DNA microarrays: cDNA microarrays, oligo DNA microarrays, BAC microarrays and SNP microarrays.

What does microarray analysis mean?

Microarray analysis is a method that makes use of gene chips to which thousands of different mRNAs can bind and be quantified.

What does microarray test for?

Microarray is a high resolution test to assess very small gains and losses (copy number variants) of genomic information and areas of homozygosity (which might suggest an autosomal recessive condition).

What is chromosomal microarray Analaysis (CMA)?

Chromosomal microarray analysis (CMA) is considered medically necessary as a first-line test in the initial postnatal* evaluation of individuals with the following: Multiple anomalies not specific to a well-delineated genetic syndrome; or Apparently non-syndromic developmental delay/intellectual disability; or Autism spectrum disorders.

What is a microarray analysis?

Microarray analysis is a DNA-based method of genetic analysis, which can identify clinically significant chromosome abnormalities that are below the resolution of conventional chromosome analysis. Microarray analysis can be performed on prenatal diagnostic samples, peripheral blood, and products of conception.