What does high NSE mean?
What does high NSE mean?
In the context of a patient with a lung mass, disseminated malignancy of unknown origin or symptoms suggestive of paraneoplastic disease without identifiable tumor, elevated NSE suggests an underlying small cell lung carcinoma (SCLC).
What is NSE in Blood Test?
Neuron Specific Enolase (NSE) – Elevated levels of serum NSE are reported in patients with small cell carcinomas primarily of lung origin. Patients with neuroblastomas may also have high levels of NSE. Serum NSE can be used to monitor recurrence or progression of tumor in these cancer patients.
Where is neuron specific enolase found?
cytoplasm
Neuron-specific enolase (NSE) was first described in 1965 and is part of the group of the glycolytic enzymes. It is found in the cytoplasm of the neurons (isoenzyme γγ) and neuroendocrine cells (isoenzyme αγ) and is considered a biomarker for neuronal injury.
What is NSE level?
Neuron specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible. The biological half-life of NSE in body fluids is approximately 24 hours.
What is Neuron test?
What is a neurological examination? A neurological examination assesses motor and sensory skills, hearing and speech, vision, coordination, and balance. It may also test mental status, mood, and behavior. The examination uses tools such as a tuning fork, flashlight, reflex hammer, and a tool for examining the eye.
What type of enzyme is enolase?
Enolase belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). The reaction is reversible, depending on environmental concentrations of substrates.
What is neuron-specific enolase test?
Description. The Neuron-specific Enolase Blood Test, or NSE Blood Test, is useful in the diagnosis and ongoing monitoring of patients with small cell lung carcinoma (SCLC). It may also be used in the diagnosis of other neuroendocrine tumors such as carcinoids, islet cell tumors and neuroblastomas.
What does neuron-specific enolase measure?
Neuron-specific enolase (NSE) is an acidic protease unique to neurons and neuroendocrine cells. It is a sensitive indicator for assessing the severity of nerve cell damage and prognosis1,2. It is also specific markers for tumors such as neuroblastoma and small cell lung cancer (SCLC)3,4.
What is NSE neurology?
Background: Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication of neurological outcome after cardiac arrest, but the relevance of recommended cutoff values has been questioned due to the lack of a standardized methodology and uncertainties over the influence of temperature management.
What a neurologist can diagnose?
A neurologist is a medical doctor with specialized training in diagnosing, treating, and managing disorders of the brain and nervous system including, but not limited to, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), concussion, epilepsy, migraine, multiple sclerosis, Parkinson’s disease, and stroke.
What is the role of enolase?
Enolase is a glycolytic enzyme, which catalyzes the inter-conversion of 2-phosphoglycerate to phosphoenolpyruvate. Altered expression of this enzyme is frequently observed in cancer and accounts for the Warburg effect, an adaptive response of tumor cells to hypoxia.
When to worry about neuron specific enolase ( NSE ) test results?
All neuron-specific enolase (NSE) test results must be considered in the clinical context, and interferences or artifactual elevations should be suspected if the clinical NSE test results are at odds with the clinical picture or other tests. The laboratory should be contacted for assistance in these situations.
What is the western blot for enolase 2?
Western Blot: Enolase 2/Neuron-specific Enolase Antibody [NB110-58870] – Blot of rat spinal cord probed with rabbit antibody to NSE. The antibody stains a single sharp band corresponing to NSE at about 47kDa.
What is the half life of neuron specific enolase?
Neuron specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible. The biological half-life of NSE in body fluids is approximately 24 hours.
Which is the dominant enolase in the neuroendocrine system?
Neuron specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible.