Is TP53 and p53 the same?

The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating the cell cycle and acts as a tumor suppressor.

Is the p53 gene a proto oncogene?

The p53 proto-oncogene can act as a suppressor of transformation. Cell 57, 1083–1093 (1989). Funk, W. D., Pak, D. T., et al. A transcriptionally active DNA-binding site for human p53 protein complexes.

What is the role of p53?

p53 functions as a transcription factor involved in cell-cycle control, DNA repair, apoptosis and cellular stress responses. However, besides inducing cell growth arrest and apoptosis, p53 activation also modulates cellular senescence and organismal aging.

What’s the difference between p53 and TP53 gene?

The p53 is a protein, while TP53 is a gene. So, this is the key difference between p53 and TP53. Actually, the TP53 gene is the gene that expresses and produces p53 tumour-suppressing protein. Moreover, p53 protein weighs of 53kDa. In contrast, TP53 gene is a 20 kb nucleotide sequence.

Is there such a thing as tumor suppressor p53?

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

What happens to Trp53 in p53 Flox mice?

When these p53 flox mice are bred to mice with a Cre recombinase gene under the control of a promoter of interest, Trp53 expression is deleted in the tissue of interest. Exons 2-10 are flanked by loxP sites in this conditional targeted mutant strain.

What is the role of p53 in the body?

Mutation is usually what causes the problem, not the amount of protein. P53 has been described as “the guardian of the genome” because of its role in conserving stability by preventing genome mutation. R If the TP53 gene is damaged, tumor suppression is severely compromised.