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Why is platelet transfusion contraindicated in ITP?

Why is platelet transfusion contraindicated in ITP?

The therapeutic benefit of platelet transfusions in the management of ITP is controversial, as transfused platelets are short-lived, and platelet transfusion has been linked with increased risk of arterial thrombosis and mortality in platelet consumptive disorders such as thrombotic thrombocytopenic purpura and heparin …

When do you transfuse platelets ITP?

The 2010 international consensus guidelines on the diagnosis and management of ITP (Blood, 2010) recommends that platelet transfusions be reserved for use when an urgent restoration in platelet count is needed, such as for patients who are bleeding and those preparing for surgery.

Why is platelet transfusion contraindicated?

The only agreed upon contraindication to platelet transfusion is thrombotic thrombocytopenic purpura (TTP) due to increased risk of thrombosis, although studies on outcomes and mortality have shown mixed results. [13][14] Platelet transfusion is reserved for life-threatening bleeding only.

When should you not transfuse platelets?

Platelet transfusion is not indicated in patients where bleeding is unrelated to proven or anticipated decreased platelet count or to functional platelet defects. 2.

Does ITP shorten lifespan?

Reduced life expectancy from related complications. There’s no cure for ITP. However, this doesn’t mean that ITP is fatal. Mortality directly related to ITP is rare, per a study published in the American Journal of Hematology .

Does ITP turn into leukemia?

ITP does not turn into a more serious blood disorder, like leukemia or aplastic anemia. It is usually not a sign that their child will later develop other autoimmune conditions, such as systemic lupus erythematosus (SLE or “lupus”).

Do you give platelets in ITP?

Platelet transfusions are frequently administered to hospitalized patients with platelet consumptive/destructive disorders such as TTP, HIT, and ITP. Platelet transfusions are associated with higher odds of arterial thrombosis and mortality among TTP and HIT patients.

When do you transfuse platelets?

Platelet transfusion is indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects. Cryoprecipitate is used in cases of hypofibrinogenemia, which most often occurs in the setting of massive hemorrhage or consumptive coagulopathy.

At what point do you transfuse platelets?

When platelet counts drop below a certain level (often 20,000/mcL), a patient is at risk for dangerous bleeding. Doctors consider giving a platelet transfusion when the platelet count drops to this level or even at higher levels if a patient needs surgery or is bleeding.

Are there any studies on platelet transfusion in ITP patients?

To date, the nationwide practices of platelet transfusion in hospitalized ITP patients in the US have not been reported. Objective. This study aims to quantify the current nationwide in-hospital ITP related bleeding complications, platelet transfusion practices and the associated mortality rates.

What are the symptoms of idiopathic thrombocytopenic purpura ( ITP ) platelet count?

What are the symptoms of idiopathic thrombocytopenic purpura? Normal platelet count is in the range of 150,000 to 450,000. With ITP, the platelet count is less than 100,000. By the time significant bleeding occurs, you may have a platelet count of less than 10,000. The lower the platelet count, the greater the risk of bleeding.

What’s the difference between ITP and thrombocytopenia?

Thrombocytopenia means a decreased number of platelets in the blood. Purpura refers to the purple discoloring of the skin, as with a bruise. ITP is a fairly common blood disorder that both children and adults can develop. There are two forms of ITP:

What is the mortality rate for ITP patients?

Mortality rate is significantly higher in ITP patients with a major bleed as compared to those without a major bleed. Platelet transfusions in patients with major bleeds are not associated with improved mortality rates.