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What is poly I:C treatment?

What is poly I:C treatment?

A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the number and tumoricidal activities of various immunohematopoietic cells.

How does poly I:C work?

Poly(I:C) is a synthetic analog of double-stranded RNA (dsRNA) that activates the signaling via TLR3 and cytoplasmic dsRNA sensors such as melanocyte differentiation-associated 5 (MDA5, also known as IFIH1) (17, 18).

What is poly I:C used for?

Polyinosinic:polycytidylic acid (poly I:C) is a synthetic analogue of double-stranded (ds)RNA, a molecular pattern associated with viral infections, that is used to exacerbate inflammation in lung injury models.

What is the ligand of TLR3?

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a PAMP associated with viral infections. The ligand of choice for TLR3 is a synthetic analog of dsRNA known as polyinosinic-polycytidylic acid (poly(I:C) or poly(rI):poly(rC)).

What is the role of IC in PolyU?

Being one of PolyU’s Administrative and Supporting Offices, IC serves to provide engineering education as well as technical & research support to researchers and students to realize their research, projects and incubation initiatives.

What kind of RNA is poly I C?

Poly I:C is a mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid .

What are the physicochemical properties of poly I-C?

Optimization of physicochemical properties of poly I:C has led to generation of derivatives that have increased stability in body fluids (such as polyICLC ), or reduced toxicity through reduced stability in body fluids (such as poly I:C 12 U). ^ Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN (2004).

What is the molecular weight of poly ( I ) C?

High Molecular Weight Poly(I:C) comprises long strands of inosine poly(I) homopolymer annealed to strands of cytidine poly(C) homopolymer.