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What is pathophysiological jaundice?

What is pathophysiological jaundice?

Post-hepatic jaundice refers to obstruction of biliary drainage. The bilirubin that is not excreted will have been conjugated by the liver, hence the result is a conjugated hyperbilirubinaemia. Pre-Hepatic. Hepatocellular. Post-Hepatic.

What does unconjugated bilirubin do?

Unconjugated bilirubin is a waste product of hemoglobin breakdown that is taken up by the liver, where it is converted by the enzyme uridine diphosphoglucuronate glucuronosyltransferase (UGT) into conjugated bilirubin. Conjugated bilirubin is water-soluble and is excreted into the bile to be cleared from the body.

What causes hepatocellular jaundice?

Hepatocellular jaundice is usually caused by liver failure, liver disease (cirrhosis), hepatitis (inflammation of the liver), or by taking certain types of medication. Haemolytic jaundice is where too much bilirubin is produced as a result of a large number of red blood cells being broken down.

What are the signs and symptoms of physiologic jaundice?

Signs and symptoms of Physiologic Jaundice are: Gradual yellowing of eyes and skin (face) initially, which then slowly spreads to the entire body, within the first week of birth. The jaundice does affect the skin tone or vitality Baby may be sleepy, lethargic, and may feed poorly.

What causes jaundice in the second day of life?

Jaundice due to these normal newborn conditions is called physiologic jaundice, and it typically appears on the second or third day of life. Other causes An underlying disorder may cause infant jaundice.

What do you need to know about infant jaundice?

1 Overview. Infant jaundice is yellow discoloration of a newborn baby’s skin and eyes. 2 Symptoms. Yellowing of the skin and the whites of the eyes — the main sign of infant jaundice — usually appears between the second and fourth day after birth. 3 Causes. 4 Risk factors. 5 Complications. 6 Prevention.

What causes abdominal pain when you have jaundice?

If the jaundice is caused by pancreatic or biliary tract cancers, the most common symptom is abdominal pain. Sometimes, you may have jaundice occurring with liver disease if you have: