Cis-acting factors are mechanisms that affect gene expression only on the same chromosomal allele, while trans-factors act equally on both alleles. Transcription factors and long noncoding RNAs are a classic example of trans-acting factors.
What is a cis-acting mutation?
Cis-acting regulatory mutations generally disrupt some facet of the transcriptional activation process . It is important to distinguish this class of mutations from those that interfere with target gene expression through other means, including mRNA splicing, stabilization, degradation, poly-adenylation, etc.
What is a cis-acting protein?
Cis-acting elements – DNA sequences in the vicinity of the structural portion of a gene that are required for gene expression. As we have mentioned several genes seem to be transcribed coordinately.
What is a cis-acting locus?
A genetic region affecting the activity of genes on that same DNA molecule. Cis-acting loci generally do not encode proteins, but rather serve as attachment sites for DNA-binding proteins. Enhancers, operators, and promoters are examples of cis-acting loci.
What is the meaning of the word Cis acting?
What does cis-acting mean? Here are all the possible meanings and translations of the word cis-acting. Describing transcription factors that regulate the expression of genes on the same chromosome. How to pronounce cis-acting?
What’s the difference between trans-acting and cis-acting elements?
Cis-acting elements, on the other hand, do not code for protein or RNA. Both the trans-acting gene and the protein/RNA that it encodes are said to “act in trans” on the target gene. ^ Brooker, Robert J. Genetics: analysis and principles (6th ed.).
How are trans and cis regulatory elements related?
Gene expression regulation is mediated by regulatory elements known as cis regulatory elements and trans regulatory elements. Cis regulatory elements are DNA sequences that are involved in regulation of gene expression by acting on DNA sequences that are present on the same side as them.
How are cis regulatory elements involved in gene expression?
Cis regulatory elements are DNA sequences that are involved in regulation of gene expression by acting on DNA sequences that are present on the same side as them.