Is oxaliplatin an irritant or vesicant?
Is oxaliplatin an irritant or vesicant?
Oxaliplatin is a novel class of platinum chermotherapeutic agent used in refractory adenocarcinoma. It has previously been regarded as a non-vesicant, and as such was considered safe to administer through peripheral veins.
Is carboplatin an irritant with vesicant properties?
Anti-cancer drug extravasation assessment tool. Clinical procedure – extravasation management – irritants with vesicant properties general care….Extravasation management table.
| Drug name | Carboplatin |
|---|---|
| Class/clinical procedure | Irritant |
| Warm or cold compress | COLD compress (initial for comfort measures) |
| Antidote | Not indicated |
What are the side effects of ifosfamide in humans?
At doses of 1.6 to 2.4 g/m 2 /day, the plasma decay is monoexponential and the terminal elimination half-life is about 7 hours. Ifosfamide exhibits time-dependent pharmacokinetics in humans. Following intravenous administration of 1.5 g/m 2 over 0.5 hour once daily for 5 days to 15 patients with neoplastic disease,…
Which is an irritant and which is a vesicant?
Some antineoplastic agents may be classified as a vesicant, others as an irritant, and some as an irritant with vesicant properties, depending on the effect on surrounding tissue when the agent leaks outside the vein.15,17 A vesicant (Box 1) is any drug that has the potential to cause tissue damage when leakage occurs outside the vein.13
How often should you take ifosfamide for bladder toxicity?
Treatment is repeated every 3 weeks or after recovery from hematologic toxicity. In order to prevent bladder toxicity, Ifosfamide for Injection should be given with extensive hydration consisting of at least 2 liters of oral or intravenous fluid per day.
What should be the concentration of ifosfamide in water?
Solutions of Ifosfamide may be diluted further to achieve concentrations of 0.6 to 20 mg/mL in the following fluids: