What type of cancer causes tumor lysis syndrome?

Tumor lysis syndrome occurs most often in patients with acute leukemia with high white blood cell (WBC) counts and in those with high-grade lymphomas in response to aggressive treatment.

Can you survive tumor lysis syndrome?

Prognosis in tumor lysis syndrome depends on the underlying malignancy characteristics. In patients with a hematologic malignancy, the mortality rate for tumor lysis syndrome is approximately 15%. The reported mortality of tumor lysis syndrome in patients with solid malignancies is reported at 36%.

What does Nccn stand for cancer?

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of 31 leading cancer centers devoted to patient care, research, and education.

How do we treat tumor lysis syndrome?

Treating tumor lysis syndrome. Treatment for tumor lysis syndrome includes hydration, which will typically be given as IV fluids, and medications, such as allopurinol (brand names Zyloprim® or Aloprim®) that stops the body from making uric acid, or rasburicase (brand name Elitek ™), which breaks down uric acid.

What are manifestations of tumor lysis syndrome?

Other manifestations of tumor lysis syndrome include the following: Lethargy. Edema. Fluid overload. Congestive heart failure.

Which tumors are associated with tumor lysis syndrome (TLS)?

Spontaneous tumor lysis syndrome (TLS) is a rare condition in solid tumors, particularly in endometrial carcinoma. Spontaneous TLS occurs without the use of cytotoxic therapy but is observed particularly in hematologic malignancies. Given the high morbidity and mortality associated with spontaneous TLS, it is crucial to identify and treat it promptly.

What does tumor lysis syndrome mean?

Tumor lysis syndrome (TLS) is a group of metabolic abnormalities that can occur as a complication during the treatment of cancer, where large amounts of tumor cells are killed off (lysed) at the same time by the treatment, releasing their contents into the bloodstream.