Who is Bravecto made by?

Merck Animal Health
Merck Animal Health Receives U.S. FDA Approval of BRAVECTO® (fluralaner) Monthly Chews.

What class of drug is fluralaner?

isoxazolines
Fluralaner (syn. A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [1, 2]. Isoxazolines are potent inhibitors of gamma-aminobutyric acid (GABA)- and glutamate-gated chloride channels in the nervous system of invertebrates [3].

How is Bravecto metabolized?

Bravecto® works by inhibiting the nervous system of insects. It does not have any effect on the nervous system of animals. In fact, it is excreted unchanged through the pet’s liver and kidneys.

What is the ingredient in Bravecto?

fluralaner
The active ingredient in Bravecto (fluralaner), an ectoparasiticide belonging to the isoxazoline group, is systematically active against fleas and ticks (black-legged tick, American dog tick, and brown dog tick), delivering protection for 12 weeks*. It also kills lone star ticks for eight weeks.

How does feeding affect the pharmacokinetics of fluralaner?

Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigated the influence of concurrent feeding on fluralaner pharmacokinetics.

How is the concentration of fluralaner measured in dogs?

Plasma samples were collected at multiple post-treatment time points for fluralaner concentration analysis. Clinical observations were performed on all dogs at regular intervals throughout the study. Fluralaner was readily absorbed in fasted and fed dogs administered at a dose of 25 mg/kg BW with a similar mean t max for both groups.

When did the FDA approve Fluralaner for dogs?

The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014 and Bravecto Plus as a topical treatment for cats in November 2019, with warnings about possible side effects in both species. The EU approved the drug in February 2014.

How long does Fluralaner work for cats and dogs?

“A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment”. Parasites & Vectors. 11 (1): 385. doi: 10.1186/s13071-018-2927-0.