What does GABA do in the pancreas?

In the pancreatic islet, GABA released from β-cells plays a critical role in the regulation of glucagon secretion from α-cells. Specifically, GABA activates GABAARs in α-cells, sequentially leading to an influx of Cl- and membrane hyperpolarization, and hence an inhibition of glucagon secretion.

What chromosome is GABRB3 on?

The GABRB3 gene is located on the long arm of chromosome 15, within the q12 region in the human genome. It is located in a gene cluster, with two other genes, GABRG3 and GABRA5.

What do GABA receptors do?

Gamma-aminobutyric acid (GABA) is an amino acid that functions as the primary inhibitory neurotransmitter for the central nervous system (CNS). It functions to reduce neuronal excitability by inhibiting nerve transmission.

How does GABA work?

Neurotransmitters function as chemical messengers. GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect.

What is the function of Gabrb3 in the brain?

The two other genes in the gene cluster both encode for related subunits of the family. During development, when the GABRB3 subunit functions optimally, its role in the GABA A receptor allows for proliferation, migration, and differentiation of precursor cells that lead to the proper development of the brain.

Where is the GABRB3 gene located on the chromosome?

In mice the Gabrb3 gene is located on chromosome 7 of its genome in a similar gene cluster style with some of the other subunits of the GABA A receptor. GABRB3 encodes a member of the ligand-gated ion channel family.

What happens if you delete the GABRB3 gene?

Angelman syndrome. Deletion of the GABRB3 gene results in Angelman syndrome in humans, depending on the parental origin of the deletion. Deletion of the paternal allele of GABRB3 has no known implications with this syndrome, while deletion of the maternal GABRB3 allele results in development of the syndrome.

How does the pancreas regulate blood sugar levels?

As part of the endocrine system, the pancreas secretes two main hormones that are vital to regulating your glucose (also known as blood sugar) level: Insulin. Glucagon: The pancreas secretes this hormone to increase blood glucose when levels get too low.