What are the side effects of checkpoint inhibitors?

The most common side effects of checkpoint inhibitors are:

• Diarrhea.
• Pneumonitis (inflammation in the lungs)
• Rashes and itchiness.
• Problems with some hormone levels.
• Kidney infections.

What are immune-related adverse events?

Immune-related adverse events (irAEs) are a unique spectrum of side effects of ICIs that resemble autoimmune responses. irAEs affect almost every organ of the body and are most commonly observed in the skin, gastrointestinal tract, lung, and endocrine, musculoskeletal, and other systems [3].

Which of the following is a common adverse event associated with immune checkpoint inhibitor therapy?

Dermatologic toxicities are the most common irAEs associated with immune checkpoint inhibition and can affect up to 50% of patients, the majority of which are low-grade severity. Typical presentations include pruritus, rash, dermatitis, and bullous dermatitis.

Are there any long term side effects of Solage?

Solagé is a dermal irritant and the results of continued irritation of the skin for greater than 52 weeks in chronic, long-term use are not known. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used only with utmost caution in patients with this condition.

What happens if you put too much Solage on your skin?

Solagé may cause the treated age spots or surrounding skin to become lighter than your normally colored skin, especially if too much Solagé is used or it is used for too long. Hyperpigmentation (darkening of skin) has also been reported as a possible side effect. Call your doctor if changes in your skin color occur .

When to discontinue the use of Solage?

If a drug sensitivity, chemical irritation, or a systemic adverse reaction develops, use of Solagé should be discontinued. Weather extremes, such as wind or cold, may be more irritating to patients using Solagé. Solagé should be used with caution by patients with a history, or family history, of vitiligo.

What are the ingredients in the drug Solage?

Solage Description. Solagé contains mequinol 2% and tretinoin 0.01%, by weight, in a solution base of ethyl alcohol (77.8% v/v), polyethylene glycol 400, butylated hydroxytoluene, ascorbic acid, citric acid, ascorbyl palmitate, edetate disodium, and purified water.