What is uterine agenesis?

Vaginal agenesis (a-JEN-uh-sis) is a rare disorder that occurs when the vagina doesn’t develop, and the womb (uterus) may only develop partially or not at all. This condition is present before birth, and may also be associated with kidney, heart or skeletal abnormalities.

What causes Mullerian agenesis?

Müllerian agenesis is caused by embryologic underdevelopment of the müllerian duct, with resultant agenesis or atresia of the vagina, uterus, or both. The vaginal canal is markedly shortened and may appear as a dimple below the urethra.

What causes a girl to be born without a uterus?

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and uterus to be underdeveloped or absent, although external genitalia are normal.

Is vaginal agenesis hereditary?

Is vaginal agenesis inheritable? There is little evidence that agenesis of the lower vagina runs in families. There are no known risk factors for vaginal agenesis.

What do you need to know about vaginal agenesis?

Vaginal agenesis. Overview. Vaginal agenesis (a-JEN-uh-sis) is a rare disorder that occurs when the vagina doesn’t develop, and the womb (uterus) may only develop partially or not at all. This condition is present before birth, and may also be associated with kidney, heart or skeletal abnormalities.

What happens to the uterus during cervical agenesis?

If untreated, the accumulation of menstrual fluid in the uterus caused by cervical agenesis can lead to hematocolpos, hematosalpinx, endometriosis, endometrioma and pelvic adhesions. Cervical agenesis arises during fetal development, during which time the paramesonephric duct fails to canalize in formation of the cervix.

How often does MUllerian agenesis occur in women?

Also referred to as Müllerian agenesis, vaginal agenesis, or müllerian aplasia, this disorder affects 1 in every 4,000-5,000 females. A cloacal malformation often accompanies this disorder, which is the surgical treatment that incorporates several vaginal replacement techniques.

What kind of pain does cervical agenesis cause?

Milder forms of the condition, in which the cervix is present but deformed and nonfunctional, are known as cervical atresia or cervical dysgenesis . Patients with cervical agenesis typically present in early adolescence, around the time of menarche, with amenorrhea and cyclic pelvic pain caused by the obstruction of menstrual flow from the uterus.