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What is the process of insulin secretion?

What is the process of insulin secretion?

Insulin secretion is a process that involves the fusion of insulin granules with the plasma membrane and exocytosis of granule content. Insulin secretion shows a characteristic biphasic pattern that consists of a transient first phase followed by a sustained second phase.

What causes insulin to secrete?

When we eat food, glucose is absorbed from our gut into the bloodstream, raising blood glucose levels. This rise in blood glucose causes insulin to be released from the pancreas so glucose can move inside the cells and be used.

How is insulin released from the beta cell?

Insulin is secreted by the β-cells of the pancreatic islets of Langerhans in response to elevation of the intracellular Ca2+ concentration ([Ca2+]i). This is produced by an influx of extracellular Ca2+ via voltage-dependent Ca2+ channels, whose activity, in turn, is regulated by the β-cell membrane potential.

What hormone stimulates insulin secretion?

Incretin Hormone. A hormone that stimulates insulin secretion in response to meals. The two most important incretin hormones are called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide ( GIP ).

What is too much secretion of insulin called?

Congenital hyperinsulinism (HI) is a genetic disorder in which the insulin cells of the pancreas, called beta cells, secrete too much insulin.

When insulin is secreted what happens?

Insulin is secreted when the level of blood glucose rises—as after a meal. When the level of blood glucose falls, secretion of insulin stops, and the liver releases glucose into the blood.

Which gland secretes insulin?

Insulin is a hormone that comes from the gland situated behind and below the stomach (pancreas). The pancreas secretes insulin into the bloodstream. The insulin circulates, enabling sugar to enter your cells. Insulin lowers the amount of sugar in your bloodstream.