What is Subepithelial deposit?

Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history.

What is C3 in kidney biopsy?

C3G stands for complement 3 glomerulopathy. The “C3” refers to a blood protein that plays a key role in normal immunity and in the development of this disease. More on this later. The “G” is for glomerulopathy, meaning damage to the glomeruli in the kidney.

What are mesangial deposits?

Mesangial deposits are granular and they can be found in IgA, IgM, and C1q nephropathies, in C3 mesangial GN, lupus nephritis class II, resolving postinfectious GN, and others. Figure 21. IgA Positivity in mesangial areas in a case of IgA nephropathy. See that capillary walls are not marked by the immunostaining.

What are the proliferating cells in endocapillary glomerulonephritis?

Endocapillary proliferative glomerulonephritis. It is an increase of the number of tuft cells occluding the glomerular capillaries and usually accompanied by mesangial hypercellularity. The proliferating cells are endothelial, mesangial, and inflammatory cells infiltrating the tuft (leukocytes).

Can a glomerular lesion be accompanied by hyaline deposits?

This glomerular lesion can be, or no, accompanied by hyaline deposits (Figure 2); the importance of this type of deposits, respect to the pathogenesis, is uncertain (see the chapter of focal and segmental glomeruloesclerosis).

How is global cellular proliferation related to glomeruli?

Global cellular proliferation with increase of the glomerular size; there is loss of capillary lumens and nuclei with variable aspect in form and size, suggesting that there are several proliferating cell types. In some cases the mesangial proliferation contributes to accentuate the lobules of the glomeruli: “lobulation”.