What does the HRAS gene do?
What does the HRAS gene do?
The HRAS gene provides instructions for making a protein called H-Ras that is involved primarily in regulating cell division. Through a process known as signal transduction, the H-Ras protein relays signals from outside the cell to the cell’s nucleus. These signals instruct the cell to grow or divide.
How many exons does HRAS gene have?
HRAS (Harvey rat sarcoma viral oncogene homolog)
Note | to be quoted is the existence of a pseudogene, c-Ha-ras 2, inactivated, processed pseudogene which is located on Chromosome X. |
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Description | consists of six exons, spread over 6.6kb of genomic DNA |
Where is HRAS gene expressed?
HRAS is expressed in the Ras/MAP kinase pathway that is also the site of germline mutations in two phenotypically overlapping conditions, Noonan syndrome and cardiofaciocutaneous syndrome.
Is GTPase HRAS usually active or inactive?
In the graphics (above and below), H-ras is shown in both active and inactive states. In its active form, the enzyme is bound to GTP. In this state H-ras helps direct mitosis in eukaryotes. When H-ras is inactive it is bound with GDP, ceasing cell replication.
How is the HRAS gene involved in cell division?
The HRAS gene provides instructions for making a protein called H-Ras that is involved primarily in regulating cell division. Through a process known as signal transduction, the H-Ras protein relays signals from outside the cell to the cell’s nucleus. These signals instruct the cell to grow or divide.
Where are HRAS, KRAS and NRAS genes located?
Human HRAS, KRAS and NRAS genes encode highly related G-proteins that reside in the inner surface of the cell membrane and transmit signals arising from cell-membrane receptor tyrosine kinases and G-protein-coupled receptors along the MAPK, PI3K/AKT and other signaling pathways.
Which is more highly conserved HRAS1 or hras2?
They concluded that the human genome contains several copies of the c-ras gene family and that c-Ha-ras-1 (with intervening sequences) (HRAS1) has been more highly conserved than has c-Ha-ras-2 (HRAS2; 300437 ).
How is HRAS expressed in the germline?
HRAS is expressed in the Ras/MAP kinase pathway that is also the site of germline mutations in two phenotypically overlapping conditions, Noonan syndrome and cardiofaciocutaneous syndrome. Angela Greco, Marco A. Pierotti, in Cancer Genomics, 2014