What are the precautions and contraindications for the tricyclic antidepressants?

Tricyclic antidepressants should be used cautiously in patients with seizures since they can increase the risk of seizures. Tricyclic antidepressants may worsen urinary retention (difficulty urinating) and narrow angle glaucoma.

Who should avoid taking tricyclic antidepressants?

People with the following conditions should avoid tricyclic antidepressants:

• angle-closure glaucoma.
• enlarged prostate.
• urinary retention.
• heart problems.
• thyroid problems.

What contraindications are associated with antidepressants?

TCAs may not be suitable if you have:

• a history of heart disease.
• recently had a heart attack.
• liver disease.
• an inherited blood disorder called porphyria.
• bipolar disorder.
• schizophrenia.
• a growth on your adrenal glands that is causing high blood pressure (pheochromocytoma)
• an enlarged prostate gland.

What is the most concerning issue with tricyclic antidepressants?

Some tricyclic antidepressants are more likely to cause side effects that affect safety, such as: Disorientation or confusion, particularly in older people when the dosage is too high. Increased or irregular heart rate. More-frequent seizures in people who have seizures.

When is a tricyclic antidepressant considered a contraindication?

Contraindications Tricyclic antidepressants are contraindicated in several populations and with the concomitant use of various medications. TCAs should not be prescribed if there is a family history of QTc interval prolongation or sudden cardiac death. Hypersensitivity reactions to a TCA drug are considered an absolute contraindication.

Can a tricyclic antidepressant be used for non neuropathic pain?

The efficacy of tricyclic antidepressants has been documented in a variety of non-neuropathic pain syndromes. Most other antidepressants and most antiepileptic drugs have little or no documented efficacy in the treatment of non-neuropathic pain.

Are there any antidepressants that are good for chronic pain?

Other antidepressants that may help. However, fluoxetine may boost the painkilling effects of some tricyclic antidepressants. SSRIs generally don’t work as well as tricyclic antidepressants for pain, but they often produce fewer side effects. Fluoxetine can cause certain side effects, such as insomnia and dizziness.

How does tricyclic antidepressant affect spinal cord pain?

Tricyclic antidepressants are thought to affect pain transmission in the spinal cord by inhibiting the reuptake of norepinephrine and serotonin, both of which influence descending pain pathways. In addition, histamine H 1 -receptor affinity (associated with sedation) may be correlated with the analgesic effect of antidepressants.