Is MIB-1 the same as Ki67?

MIB-1. Ki-67 and MIB-1 monoclonal antibodies are directed against different epitopes of the same proliferation-related antigen. Ki-67 and MIB-1 may be used on fixed sections. MIB-1 is used in clinical applications to determine the Ki-67 labelling index.

Which antibody is raised against Ki67?

MIB-1 is an anti-Ki67 monoclonal antibody that is immunoreactive for the nuclei of cells in non-G0 phases. The ratio of MIB-1–positive cells (MIB-1 index) is reported to correlate well with histologic grading. A high immunohistochemical proliferation index is found to be associated with increased risk of recurrence.

When to use Ki-67 and MIB-1 monoclonal antibodies?

Ki-67 and MIB-1 monoclonal antibodies are directed against different epitopes of the same proliferation-related antigen. Ki-67 and MIB-1 may be used on fixed sections. MIB-1 is used in clinical applications to determine the Ki-67 labelling index.

How are Ki-67 and MIB-1 proliferation indices used?

Ki-67 and MIB-1 median values were used to obtain two groups of patients at different risk and life-table analysis (Mantel-Cox) was performed to assess the probabilities of overall survival (OS) and relapse-free survival (RFS). The median time of observation was 61 months.

How is the Ki-67 protein used in immunohistochemistry?

Use as a marker of proliferating cells Ki-67 immunostaining of a brain tumour with a high proliferative rate. The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation, and can be used in immunohistochemistry. It is strictly associated with cell proliferation.

How does the Ki-67 proliferation marker test work?

While the Ki-67 proliferation marker test is increasingly ordered by doctors, its overall benefit, specifically when it comes to making decisions about treatment, is not certain. Your doctor may order the Ki-67 test as a way to measure how quickly your breast cancers cells are dividing and forming new cells.