Is Dess-Martin Periodinane toxic?
Is Dess-Martin Periodinane toxic?
The Dess–Martin oxidation may be preferable to other oxidation reactions as it is very mild, avoids the use of toxic chromium reagents, does not require large excess or co-oxidants, and for its ease of work up….
| Dess–Martin oxidation | |
|---|---|
| RSC ontology ID | RXNO:0000256 |
How do you quench Dess-Martin Periodinane?
Work up of Dess-Martin periodinane involves simple filtration of the reduced product . By adding With few ml of water will hydrolyse DMP to insoluble IBX. Then filter precipitated IBA and IBX, using any common organic solvents, depending on the solubility of your product.
What is DMP Orgo?
The Dess-Martin Periodinane (DMP), a hypervalent iodine compound, offers selective and very mild oxidation of alcohols to aldehydes or ketones. The oxidation is performed in dichloromethane or chloroform at room temperature, and is usually complete within 0.5 – 2 hours.
What kind of reagent is Dess Martin periodinane?
Dess–Martin periodinane (DMP) is a chemical reagent used in the Dess–Martin oxidation, oxidizing primary alcohols to aldehydes and secondary alcohols to ketones.
How long does it take for Dess-Martin periodinane to oxidation?
The Dess-Martin Periodinane (DMP), a hypervalent iodine compound, offers selective and very mild oxidation of alcohols to aldehydes or ketones. The oxidation is performed in dichloromethane or chloroform at room temperature, and is usually complete within 0.5 – 2 hours.
How many EQs are in Dess Martin periodinane?
A ca. 0.05-0.35 M solution of the alcohola in dryb CH2Cl2,c containing 1 to 5 equivalents—typically 1.5 eq.—of Dess-Martin periodinaned (MW = 424.14; WARNING: this oxidant can explode) is stirrede at room tem-peraturef till most of the starting compound is consumed.
Is it possible to neutralize Dess Martin periodinane?
It is possible to perform an oxidation with Dess-Martin periodinane under almost neutral conditions by adding pyridine to the reaction flask in order to neutralize the acetic acid, which is generated during the oxidation, and performing the work-up by treatment with sodium thiosulfate in the presence of a sodium bicarbonate buffer.2