How does obesity affect coagulation?

Obesity is characterized by multiple hemostatic disturbances in blood coagulation, including enhanced platelet activation ((1)), increased concentrations, and enhanced activities of plasma coagulation factors ((2),(3),(4)) as well as impaired fibrinolysis in form of increased production of plasminogen activator …

What coagulation factors would most likely be elevated in obese patients?

Finally, inflammatory conditions such as obesity are associated with elevated plasma levels of certain coagulation factors, such as fibrinogen, von Willebrand factor, and factor VIII [20]. These effects are likely mediated by actions of inflammatory cytokines on hepatocytes and endothelial cells.

Can obesity cause blood disorders?

Obesity is a serious medical condition that can cause complications such as metabolic syndrome, high blood pressure, atherosclerosis, heart disease, diabetes, high blood cholesterol, cancers and sleep disorders.

Does obesity increase D dimer?

Since increase in body size is associated with coagulation activation, D-dimer is elevated in many obese patients making this laboratory tool irrelevant in excluding thrombosis.

What are the effects of obesity on blood coagulation?

Obesity is characterized by multiple hemostatic disturbances in blood coagulation, including enhanced platelet activation (1), increased concentrations, and enhanced activities of plasma coagulation factors (2,3,4) as well as impaired fibrinolysis in form of increased production of plasminogen activator inhibitor‐1 (PAI‐1) (5).

When do derangements of coagulation and fibrinolysis occur?

Derangements of blood coagulation and fibrinolysis are present already in early adulthood in obese subjects. Acquired obesity, independent of genetic factors, increases the activities of fibrinogen and activities of FIX, FXI, FXII, and PAI‐1.

How does obesity increase the activity of Fix and FXII?

Acquired obesity, independent of genetic factors, increases the activities of fibrinogen and activities of FIX, FXI, FXII, and PAI‐1. This study confirms the mechanisms of simultaneous activities of intrinsic coagulation factors and impaired fibrinolysis predisposing obese subjects to thrombosis.

How many obesity discordant twin pairs are there?

Fourteen obesity‐discordant (BMI within‐pair difference >3 kg/m 2) and 10 concordant (BMI difference <2 kg/m 2) MZ twin pairs were identified from the nationwide FinnTwin16 study.