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Can proton pump inhibitors cause stomach cancer?

Can proton pump inhibitors cause stomach cancer?

Two studies conducted in 2017 and 2018 concluded that long-term use of PPIs may increase the risk of stomach cancer, also called gastric cancer. Researchers at the University of Hong Kong studied more than 60,000 patients who took PPIs to treat H. pylori.

Does PPI increase risk of gastric cancer?

Recently, two epidemiological studies showed that long-term treatment with proton pump inhibitors (PPIs) increased the risk of gastric cancer. It is well known that hypergastrinemia predisposes to gastric neoplasia in animals as well as man.

Is omeprazole good for stomach cancer?

A Hong Kong study published in 2017 suggested that people taking PPIs like omeprazole for at least 3 years have a very small increased chance of developing stomach cancer. For every 10,000 people taking a PPI long term, it was thought an extra 4 people get stomach cancer.

Does omeprazole cause stomach cancer?

Emerging evidence from a number of studies suggests there is an association between long-term use of proton pump inhibitors and the development of gastric cancer.

How do I know if I have stomach cancer?

“Vague” discomfort in the abdomen above the navel. Abdominal pain or discomfort. Upper abdomen fullness below the chest bone after consuming a small amount of food. Unintentional weight loss.

Is Gaviscon safer than omeprazole?

Tolerance and safety were good and comparable in both groups. Conclusion: Gaviscon® was non-inferior to omeprazole in achieving a 24-h heartburn-free period in moderate episodic heartburn, and is a relevant effective alternative treatment in moderate GERD in primary care.

What is the safest antacid to take long term?

Oral pantoprazole is a safe, well tolerated and effective initial and maintenance treatment for patients with nonerosive GERD or erosive esophagitis.

Can omeprazole hide stomach cancer symptoms?

Proton Pump Inhibitors (PPIs) are widely used to treat acid reflux and dyspepsia. NICE cautions that PPIs can mask or alter symptoms of stomach cancer, leading to later diagnoses.

Where Does stomach cancer usually start?

Stomach cancer most commonly begins in the cells that line the inside of the stomach.