Useful tips

What is the ED95 of rocuronium?

What is the ED95 of rocuronium?

In common with vecuronium, rocuronium is a monoquaternary aminosteroid, but it is much less potent, with an ED95 (the dose required to produce 95 % depression of the twitch response) of 0.3 mg kg91 [3]. This lack of potency is thought to be an important factor in determining onset of neuro- muscular block [4].

What is the ED95 of succinylcholine?

The effective dose (ED95) of succinylcholine is less than 0.3 mg/kg. The dose of 1 mg/kg represents 3.5 to 4 times the ED(95).

Why atracurium is indicated during surgery?

Atracurium is indicated as an addition to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation.

How long does it take for a maintenance dose of atracurium?

After an initial dose of 0.4 to 0.5 mg/kg under balanced anesthesia, the first maintenance dose (suggested maintenance dose is 0.08 to 0.10 mg/kg) is generally required within 20 to 45 minutes, and subsequent maintenance doses are usually required at approximately 15 to 25 minute intervals.

How many mg of atracurium is needed to cause paralysis?

As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing atracurium doses. The ED95 (dose required to produce 95% suppression of the muscle twitch response with balanced anesthesia) has averaged 0.23 mg/kg (0.11 to 0.26 mg/kg in various studies).

When did Atracurium besilate become an essential medicine?

Atracurium was approved for medical use in the United States in 1983. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. Atracurium is available as a generic medication.

What are the side effects of atracurium besylate?

Atracurium Besylate Injection is a skeletal muscle relaxantused in addition to general anesthesia, to facilitate endotracheal intubationand to provide skeletal musclerelaxation during surgery or mechanical ventilation. Atracurium besylate injection is available in genericform. Common side effects of atracurium besylate injection include: