What happens if you overdose on baclofen?

Common manifestations of a baclofen overdose include: respiratory depression, lack of tendon reflexes, hypotonia, coma, hypothermia, bradycardia and possible seizures and cardiac conduction abnormalities. In most cases, with assisted ventilation and supportive treatment, patients fully recover within 48–72 h.

How long does baclofen overdose last?

Intoxication will develop within 2 hours, delirium is most evident just prior to the onset of coma. The duration of coma can last 24 – 48 hours.

What is baclofen toxicity?

Background: Baclofen is a gamma-aminobutyric acid (GABA) type-B receptor agonist used for muscle spasticity. Symptoms of baclofen toxicity include confusion, somnolence, nausea/vomiting, myoclonus, hypotonia, coma, seizures, and autonomic dysfunction.

What is the maximum amount of baclofen per day?

Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.

What are the effects of an overdose of baclofen?

Baclofen overdose causes mainly neurological effects and excepting hypertension cardiovascular effects were uncommon. Doses greater than 200 mg were predictive of patients developing delirium, coma and seizures, requiring long hospital admissions and ICU admission. Baclofen overdose: defining the spectrum of toxicity

When to call 911 for a baclofen overdose?

Symptoms of baclofen overdose include the following: If you or someone you know is experiencing these symptoms and has taken baclofen, call 911 immediately. Because baclofen is such a dangerous drug to overdose on, it is important to know the proper dosages. Baclofen comes in tablets of 10 mg and 20 mg dosages.

How often should I take baclofen in a day?

12 years and older: Oral: -Initial dose: The following gradually increasing dosage regimen is suggested, but should be adjusted to suit individual patient requirements: 5 mg orally 3 times a day for 3 days, then 10 mg orally 3 times a day for 3 days, then 15 mg orally 3 times a day for 3 days, then 20 mg orally 3 times a day for 3 days.

When was baclofen made available to the public?

February 2012. Baclofen is a centrally acting skeletal muscle relaxant currently available in oral formulations and intrathecal solutions. Baclofen is an agonist at gamma-aminobutyric acid B (GABA. B. ) receptors.