What does BMAL1 stand for?

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm.

Is BMAL1 a CLOCK gene?

This protein is a circadian transcription factor, and its gene is a direct CLOCK:BMAL1 target. Like CLOCK:BMAL1, REV-ERBα rhythmically binds to DNA, with higher binding at the end of the light phase (Feng et al.

Is BMAL1 a protein?

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the Bmal1 gene, also known as ARNTL, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC.

What does CLOCK gene do?

Clock genes are components of the circadian clock comparable to the cogwheels of a mechanical watch. They interact with each other in an intricate manner generating oscillations of gene expression. Positive elements activate the expression of negative elements, which in turn stop the activity of the positive elements.

How many amino acids are in the BMAL1 protein?

The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms.

How is BMAL1 related to SULT1A1 expression?

Sult1a1 is one of three Sult genes showing diurnal expressions ( Zhang et al., 2009 ). In this study, we aimed to investigate a potential role of Bmal1 in circadian regulation of Sult1a1 in mice. Sult1a1 expressions in the livers of wild-type and Bmal1-knockout mice were determined every 4 hours around the clock.

Where does BMAL1 target in the human genome?

BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

How does BMAL1 affect cyp3a11 in mice?

Cellular regulation of Cyp3a11 by Bmal1 is Dbp- and Hnf4α-dependent. Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure.