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What causes platelet clumping in EDTA?

What causes platelet clumping in EDTA?

2, 3 Platelet clumping in the presence of EDTA is caused by an autoantibody against glycoprotein IIb/IIIa located on the cell membrane of platelets. 4, 5 Although other anticoagulants such as heparin and sodium citrate rarely induce such a phenomena, it is possible.

What causes platelets to clump together?

Causes of platelet clumping include platelet activation (due to traumatic venipuncture) and EDTA-dependent antibodies that react with platelet glycoprotein IIb/IIIa. In the latter case, the clumping can be corrected by using blood collection tubes containing an alternative anticoagulant, such as sodium citrate.

What medications can cause platelet clumping?

Other medicines that cause drug-induced thrombocytopenia include:

  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.

Can platelet clumping cause blood clots?

If your blood has too many platelets, you may have a higher risk of blood clots. When the cause is unknown, this is called thrombocythemia.

Why are my platelets dropping?

There are different reasons for drop in platelets count. Dengue, malaria and viral fever are primary causes for fall in the number of platelets. This condition may also occur due to hereditary causes, and medications.

Is 134 platelet low?

Levels may vary slightly from lab to lab, but the values you show are about average. A platelet count of 134 is low, but not excessively so. Some medications may also alter platelet levels. Aspirin is one of these, so a slightly low platelet count may be considered a normal or even desired variant.

What is a normal platelet count?

The range of normal platelet count is from 1, 50, 000 to 4, 50, 000 platelets per micro liter of blood.

What does lack of platelets in the blood mean?

Low platelet count, medically called thrombocytopenia, is a health disorder where there is an abnormally low amount of platelets in your blood. Platelets are the smallest of blood cells that help in the blood clotting process. As such, low platelet count is often associated with abnormal bleeding.