Which drug inhibits the metabolism of chlordiazepoxide?

Cimetidine has been shown to inhibit the liver microsomal metabolism of the benzodiazepines diazepam and chlordiazepoxide, resulting in an increase in half-life and decrease in the clearance of these two drugs.

How is chlordiazepoxide metabolized?

Chlordiazepoxide is metabolized to long-acting metabolites in the liver to the active metabolite nordiazepam (desmethyldiazepam) and the clearance of the drug is reduced considerably in the elderly and in patients with hepatic disease.

Is chlordiazepoxide metabolized in the liver?

Chlordiazepoxide is metabolized extensively in the liver and has a prolonged half-life. The liver injury from benzodiazepines is probably due to a rarely produced metabolic intermediate metabolite.

Is Librium metabolized by the liver?

Benzodiazepines (applies to Librium) renal/liver disease. Benzodiazepines are metabolized by the liver, and the metabolites are excreted in the urine.

How long can I take chlordiazepoxide?

Do not stop taking this medication or take fewer doses without talking to your doctor. Stopping chlordiazepoxide suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Your doctor probably will decrease your chlordiazepoxide dose gradually.

Is Librax bad for liver?

Tell your doctor right away if any of these rare but serious side effects occur: signs of infection (such as fever, persistent sore throat), signs of liver problems (dark urine, persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes/skin, unusual tiredness).

Is taking Xanax bad for your liver?

Some people experience elevated liver enzymes when using Xanax long-term. This may be a sign of liver inflammation, a condition that can lead to or result from damage to liver tissue. Liver damage is even more likely if Xanax is combined with alcohol.

Are Benzos bad for your liver?

As a class, the benzodiazepines do not cause significant serum enzyme elevations and have been linked to only very rare instances of acute, symptomatic liver disease.

Does chlordiazepoxide help with anxiety?

Chlordiazepoxide is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect.

What is the metabolic pathway of chlordiazepoxide?

Chlordiazepoxide was the first benzodiazepine derivative made available for clinical use. The metabolic pathway of chlordiazepoxide is complex, since the drug is biotransformed into a succession of pharmacologically active products: desmethylchlordiazepoxide, demoxepam, desmethyldiazepam, and oxazepam.

Is there any liver damage from chlordiazepoxide?

As with other benzodiazepines, chlordiazepoxide therapy is not associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from chlordiazepoxide has been reported, but is very rare. Chlordiazepoxide is a Benzodiazepine. The chemical classification of chlordiazepoxide is Benzodiazepines.

What kind of drug is chlordiazepoxide used for?

Chlordiazepoxide is a Benzodiazepine. The chemical classification of chlordiazepoxide is Benzodiazepines. Chlordiazepoxide is an orally available benzodiazepine used for therapy of anxiety and alcohol withdrawal syndromes.

Are there any withdrawal symptoms from chlordiazepoxide?

Withdrawal from chlordiazepoxide or other benzodiazepines often leads to withdrawal symptoms that are similar to those seen with alcohol and barbiturates. The higher the dose and the longer the drug is taken, the greater the risk of experiencing unpleasant withdrawal symptoms. Withdrawal symptoms can, however,…