What is bioisosterism in drug design?

In drug design, the purpose of exchanging one bioisostere for another is to enhance the desired biological or physical properties of a compound without making significant changes in chemical structure. The main use of this term and its techniques are related to pharmaceutical sciences.

What is meant by bioisosterism?

bioisosterism (plural bioisosterisms) (pharmacology) The relationship between bioisosteres, substituents or groups with similar physical or chemical properties that impart similar biological properties to a chemical compound.

What is Bioisosteric replacement?

A bioisosteric replacement transforms an active compound into another compound by exchanging a group of atoms with another, broadly similar group of atoms. Several computational methods have been described to automatically identify bioisosteric replacements.

What is a classical Isostere?

Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere.

What is Isosterism and Bioisosterism?

Isosterism and Bioisosterism Replacement or modification of functional group with other group having similar properties is known as isosteric and bioisosteric replacement.

What is Isoters?

Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. This is a consequence of their identical electron arrangements. The term isosteres is not frequently heard in chemistry; the term bioisostere is commonly used in drug development.

Is used for bioisosteric replacement of benzene?

1]pentane were validated as saturated bioisosteres for para-substituted benzenes in medicinal chemistry projects. It was shown that such replacement increases the water solubility, lowers lipophilicity and retains bioactivity of compounds.

Which is used for bioisosteric replacement of benzene ring?

The replacement of para-substituted benzenes with saturated bi- and polycyclic bioisosteres – bicyclo[1.1. 1]pentane, bicyclo[2.2. 2]octane and cubane, – often increases the potency, selectivity and metabolic stability of bioactive compounds.

What is Isosteres example?

Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. Example 1. Consider neon, the noble gas at the end of the second row of the periodic table.

What are examples of Isosteres?

Definition of Isosteres

• What are Isosteres? Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons.
• Example 1. Consider neon, the noble gas at the end of the second row of the periodic table.
• Example 2.
• Example 3.
• :N:::N: :C:::O: :C:::N:

What is the difference between Isosteres and bioisosteres?

Friedman (1951): Bioisosteres are atoms or molecules that fit the broadest definition for isosteres and have the same type of biological activity. Thornber (1979): Groups or molecules which have chemical and physical similarities producing broadly similar biological effects.

What is Biosteric replacement?

Bioisosteres – A bioisostere is a molecule resulting from the exchange of an atom or of a group of atoms with an alternative, broadly similar, atom or group of atoms. The objective of a bioisosteric replacement is to create a new molecule with similar biological properties to the parent compound.

How is bioisosterism used to design new drugs?

Bioisosterism is a strategy of Medicinal Chemistry for the rational design of new drugs, applied with a lead compound (LC) as a special process of molecular modification (1). The LC should be of a completely well known chemical structure and possess an equally well known…

Which is the best classification of bioisosterism?

CLASSIFICATION OF BIOISOSTERISM: Classic [12] (Scheme 2 ). Scheme 2. as classic bioisosteres. (Table 1 ), while non-classic definitions of the first class (Table 2 ). literature [6-7]. 4. BIOISOSTERISM AS A STRATEGY OF inhibitors or anti-metabolites.

Which is an example of a rational drug design?

References 3172 of cancer chemotherapeutics and in the elucidation of mechanism (s) of carcinogenesis. for the rational modification of lead compounds into I. Introduction safer and more clinically effective agents.

Can a bioisosteric group be considered an identical group?

Bioisosteric can be considered identical (Table 3). replacements of functional groups based on this Table 3.