Users' questions

Is BRCA2 estrogen positive?

Is BRCA2 estrogen positive?

This retrospective study looked at the prognostic impact of estrogen receptor (ER) status on survival among women with BRCA2-mutated breast cancer. Most BRCA2-mutated patients were ER-positive.

What kind of cancer does HRT cause?

Estrogen-only HRT increases the risk of breast cancer, but only when used for more than 10 years. Estrogen-only HRT also can increase the risk of ovarian cancer. The higher breast cancer risk from using HRT is the same for so-called “bioidentical” and “natural” hormones as it is for synthetic hormones.

When should you not take HRT?

But HRT may not be suitable if you: have a history of breast cancer, ovarian cancer or womb cancer. have a history of blood clots. have untreated high blood pressure – your blood pressure will need to be controlled before you can start HRT.

Is HRT still linked to breast cancer?

Most types of HRT increase the risk of breast cancer. But the risk is higher for those using combined HRT, which uses both oestrogen and progestogen. Vaginal oestrogens are not linked to an increased risk of breast cancer, whereas tibolone is. Taking HRT for 1 year or less only slightly increases breast cancer risk.

When to use hormone therapy for BRCA gene carriers?

A useful article published in “Menopause” has reviewed current information on the effect on breast cancer risk with the use of HRT after removal of ovaries for risk reducing surgery in women who carry the BRCA gene. BRCA1 gene is associated with risk of breast cancer by age 70 of 60% to 65% and of ovarian cancer of 39% to 59%.

Is the BRCA2 gene associated with breast cancer?

BRCA2 gene is associated with risk of breast cancer by age 70 of 45% to 55% and of ovarian cancer of 11% to 17%. It is known that removal of both ovaries and Fallopian tubes in premenopausal women reduces ovarian, fallopian tube and peritoneal cancer risks by 72% to 80%, and reduces breast cancer risks by 46% to 48% in these women.

When does HRT increase the risk of breast cancer?

Using HRT (Hormone Replacement Therapy) Combination HRT also increases the likelihood that the cancer may be found at a more advanced stage, as well as increasing the risk that a woman diagnosed with breast cancer will die from the disease. Breast cancer risk increases the most during the first 2 to 3 years of taking combination HRT.

Can a hormone replacement therapy cause breast cancer?

The hormones in HRT can cause hormone-receptor-positive breast cancers to develop and grow.