What is IgA MGUS?

IgG and IgA MGUS are defined by a M-protein less than 30 g/L, bone marrow (BM) plasma cell percentage less than 10%, and absence of signs or symptoms related to multiple myeloma (MM) (hypercalcemia, renal insufficiency, anemia, or bone lesions) or other lymphoproliferative malignancies such as Waldenström’s …

Does MGUS weaken your immune system?

In both disorders, there is an increased risk of infection due to the immunosuppressive effects of disease and conjointly of therapy in MM, and response to vaccination to counter infection is compromised. The underlying factors in a weakened immune response in MGUS and MM are as yet not fully understood.

Can MGUS cause stomach problems?

Amyloidosis is a common complication of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma (MM). This proteinaceous material can be deposited intercellularly in any organ system, including the gastrointestinal (GI) tract.

How serious is MGUS?

However, people with MGUS have a slightly increased risk of developing blood and bone marrow diseases. These include serious blood cancers, such as multiple myeloma or lymphoma. Sometimes, healthy cells in the bone marrow can get crowded out when the body makes very large amounts of M proteins .

Is MGUS a blood disorder?

Monoclonal Gammopathy of Undetermined Significance or MGUS is an asymptomatic blood disorder “in which a paraprotein is found in the blood during standard laboratory blood tests” according to Wikipedia. The good news is that MGUS blood disorder is relatively harmless.

How do I treat MGUS blood?

There’s no way to treat MGUS. It doesn’t go away on its own, but it doesn’t usually cause symptoms or develop into a serious condition. A doctor will recommend regular checkups and blood tests to keep an eye on your health. Usually, these checkups start six months after first diagnosing MGUS.

What is MGUS cancer?

MGUS (monoclonal gammopathy of unknown significance) is a non-cancerous condition where the body makes an abnormal protein, called a paraprotein. MGUS is not a cancer, but people with it have a slightly higher risk of developing: myeloma (a cancer of blood cells called plasma cells) lymphoma (a cancer of blood cells called lymphocytes).