What is FK 506 level?

What is FK 506 level?

Trough concentrations of FK 506 in blood and plasma were determined by an enzyme immunoassay. Blood concentrations ranged from 0.5 to 391 ng/ml and from 0.5 to 616 ng/ml after intravenous and oral doses, respectively. The corresponding plasma levels ranged from 0.05 to 56 ng/ml and from 0.05 to 104 ng/ml, respectively.

What is a tacrolimus level?

The tacrolimus test is used to measure the amount of the drug in the blood to determine whether the concentration has reached a therapeutic level and is below the toxic level.

What tube is used for tacrolimus level?

ORDERING INFORMATION: Geisinger Epic Procedure Code: LAB3130 Geisinger Epic ID: 21539
Specimen type: Whole blood
Preferred collection container: 3 mL lavender-top (K2 EDTA) tube
Specimen required: 1 mL whole blood; minimum 0.5 mL.

What do you need to know about the FK506 test?

FK506 test, also referred to as TAC test or tacrolimus test, is often conducted to determine the level of the drug tacrolimus in blood, thus establishing dosing regimen, maintaining therapeutic levels, and detecting toxic levels.

What’s the normal 12 Hour trough concentration of FK506?

Normal 12-hour trough concentrations of FK506 are 5.0-20.0 ng/ml; Normal 24-hour trough concentrations of FK506 are 33%-50% less than that of 12-hour trough. Lower concentrations of FK506 than normal therapeutic range means rejection of the transplanted organ. Keywords: TAC; FK506; Tacrolimus

When to take a tacrolimus FK506 test?

If you have started your tacrolimus therapy, you need to get tests frequently at first, and then monitor concentrations over time at regular intervals. Higher concentrations of FK506 than normal therapeutic range increase the risk of associated toxicity such as kidney damage and nerves damage.