What is defibrotide used for?

Defibrotide injection is used to treat adults and children with hepatic veno-occlusive disease (VOD; blocked blood vessels inside the liver, also known as sinusoidal obstruction syndrome), who have kidney or lung problems after receiving a hematopoietic stem-cell transplant (HSCT; procedure in which certain blood cells …

How much does Defibrotide cost?

The cost for Defitelio intravenous solution (80 mg/mL) is around $9,994 for a supply of 25 milliliters, depending on the pharmacy you visit….Intravenous Solution.

What is sinusoidal obstruction syndrome?

Listen to pronunciation. (SINE-yoo-SOY-dul ub-STRUK-shun SIN-drome) A condition in which some of the veins in the liver are blocked. This causes a decrease in blood flow inside the liver and may lead to liver damage.

What are the Common side effects of defibrotide?

Common side effects may include: 1 nausea, vomiting, diarrhea; 2 dizziness; or 3 nosebleeds.

How long does Defibrotide stay in your system?

Defibrotide is usually given for at least 21 days, to a maximum of 60 days if symptoms have not fully improved. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Defibrotide must be mixed with a liquid (diluent) before using it.

Do you have to mix Defibrotide with a liquid?

Defibrotide must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine. Do not mix defibrotide with other medicines in the same IV line.

How long do you take defibrotide for VOD?

Defibrotide dosing information. Usual Adult Dose for Hepatic Veno-Occlusive Disease: Duration of therapy: Minimum of 21 days; if signs and symptoms of hepatic veno-occlusive disease (VOD) remain after 21 days, continue this drug until resolution of VOD or up to a maximum of 60 days.