What does prothrombin complex concentrate contain?

It is a balanced concentrate, containing a defined concentration of the four vitamin K-dependent clotting factors (II, VII, IX and X) and the thrombo-inhibitor proteins C and S. Interestingly, it is the only PCC containing antithrombin in addition to heparin.

What is 3 factor PCC?

… 3-factor PCC – 3-factor PCC (eg, Profilnine) contains only factors II, IX, and X, in an unactivated form. Activated PCC – Activated PCC (aPCC)… a 4-factor prothrombin complex concentrate (PCC) is the preferred agent for the acute reversal of warfarin anticoagulation.…

What is prothrombin complex used for?

Prothrombin complex human contains coagulation factors II, VII, IX, and X, and proteins C and S. This medicine is used to stop bleeding by helping the blood to clot.

How quickly does PCC work?

Results: 1) PCC corrected INR much faster than FFP. FFP is a slow drip over hours, PCC is a fast drip usually infused over less than an hour, sometimes minutes.

Which is the best four factor prothrombin concentrate?

 Kcentra is a four-factor prothrombin complex concentrate (4F-PCC) of coagulation factors II, VII, IV, and X, prepared from U.S. sourced plasma. Kcentra is therapeutically equivalent to Beriplex, which has been marketed outside of the US since 1996.

What are the side effects of prothrombin complex concentrate?

It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. It may also be used in those with not enough of these factors due to other reasons such as warfarin therapy. It is given by slow injection into a vein. Common side effects include allergic reactions, headache, vomiting, and sleepiness.

Who are the manufacturers of prothrombin complex concentrate ( PCC )?

Current products available Generic name Product name Company Type PCC Beriplex CSL Behring www.cslbehring.co.uk Pooled plasma product PCC Octaplex Octapharma http://www.octapharma.c om/corporate/ Pooled plasma product PCC Prothromplex T Baxter Immuno www.baxter.com Pooled plasma product 3.

How is prothrombin complex concentrate used in hemophilia B?

Prothrombin complex concentrate. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. It may also be used in those with not enough of these factors due to other reasons such as warfarin therapy. It is given by slow injection into a vein.