What does IL-13 do in asthma?

What does IL-13 do in asthma?

IL-13 and Eosinophil Activation in Asthma. Type 2 cytokines, including IL-13, regulate the secretion of various chemokines that can bind to eosinophils via the CCR3 receptor leading to eosinophil activation and migration to the lung via chemotaxis.

What is the function of IL-13?

In the lung, IL-13 is the central mediator of allergic asthma, where it regulates eosinophilic inflammation, mucus secretion, and airway hyperresponsiveness.

What does IL-4 do in asthma?

Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to …

Which interleukin causes asthma?

These results suggest that atopic asthma is associated with activation of the interleukin-3, interleukin-4, interleukin-5, and GM-CSF gene cluster, a pattern that is consistent with a Th2-like T-lymphocyte response [85].

What is the role of IL-13 in allergic inflammation?

However, IL-13 is suspected to be the central mediator of the physiologic changes induced by allergic inflammation in many tissues. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties.

What is the role of interleukin 13 in asthma?

Interleukin 13. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma.

What happens to lung cells with IL 13 deficiency?

Studies of IL-13 transgenic mice lungs with IL-13Rα2 null loci indicated that IL-13Rα2 deficiency significantly augmented IL-13 or ovalbumin-induced pulmonary inflammation and remodeling. Most normal cells, such as immune cells or endothelial cells, express very low or undetectable levels of IL-13 receptors.

Which is monoclonal antibody targets IL-4 and IL-13?

Dupilumab is a monoclonal antibody IL-13 and IL-4 modulator that targets the shared receptor of IL-4 and IL-13, IL4Rα. Since IL-4 and IL-13 have similar biological activities, dupilumab may be an effective form of treatment for asthmatic patients.