What do muscarinic drugs do?

What do muscarinic drugs do?

Drugs that bind to and activate muscarinic cholinergic receptors. Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.

What are muscarinic effects?

Muscarinic effects by organ system include the following: Cardiovascular – Bradycardia, hypotension. Respiratory – Rhinorrhea, bronchorrhea, bronchospasm, cough, severe respiratory distress. Gastrointestinal – Hypersalivation, nausea and vomiting, abdominal pain, diarrhea, fecal incontinence.

What are the effects of muscarinic agonist?

Muscarinic agonist mimics the action of acetylcholine on muscarinic receptors and causes cardiac slowing, contraction of smooth muscles (intestinal tract, bronchioles, detrusor muscle, urethra, and iris muscle), and increase secretion from exocrine glandular tissues (salivary, gastric acid, and airway mucosal gland).

What drugs affect muscarinic receptors?

Important muscarinic antagonists include atropine, Hyoscyamine, hyoscine butylbromide and hydrobromide, ipratropium, tropicamide, cyclopentolate, pirenzepine and scopalamine.

What are the side effects of muscarinic antagonists?

Relatively large doses of atropine are required to inhibit acid secretion, and side effects such as dry mouth, tachycardia, ocular disturbances, and urinary retention are drawbacks to the use of muscarinic antagonists in the treatment of peptic ulcers.

Are there any other drugs that work like muscarinic?

The mechanism of relaxation is not known. Finally, some other classes of drugs can act in part as muscarinic an- tagonists. For example, the antipsychotics and antide- pressants produce antimuscarinic side effects (e.g., dry mouth). PHARMACOLOGICAL ACTIONS

Can a drug block the activation of muscarinic receptors?

Muscarinic antagonists have no intrinsic activity, and they can produce effects only by blocking the activation of muscarinic receptors by muscarinic agonists or by neuronally released ACh.

What happens to your body when you overdose on muscarinic?

Overdose produces confusion, agitation and sleeplessness that can last up to or more than 24 hours. Pupils become dilated and unreactive to light. Tachycardia (fast heart beat), as well as auditory and visual hallucinations (nM). The smaller the value, the more strongly the drug binds to the site. (nM).