What chromosome is synuclein alpha found on?
What chromosome is synuclein alpha found on?
Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release….Alpha-synuclein.
| SNCA | ||
|---|---|---|
| Location (UCSC) | Chr 4: 89.7 – 89.84 Mb | Chr 6: 60.73 – 60.83 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
Where is the GBA gene located?
GBA is a gene located on chromosome 1 (1q21) encoding for the glucocerebrosidase (GCase), a lysosomal enzyme involved in the metabolism of glucosylceramide.
What chromosome is Parkinson disease on?
To date, two genes responsible for familial Parkinson’s disease have been identified: one is the alpha-synuclein gene located in the long arm of chromosome 4, and the other is the parkin gene located in the long arm of chromosome 6.
What does SNCA gene stand for?
SNCA (Synuclein Alpha) is a Protein Coding gene. Diseases associated with SNCA include Dementia, Lewy Body and Parkinson Disease 1, Autosomal Dominant. Among its related pathways are Ectoderm Differentiation and Parkinsons Disease Pathway.
Where is the SNCA gene located in the brain?
The SNCA gene provides instructions for making a small protein called alpha-synuclein. Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals.
Where is the upstream repeat located in the SNCA gene?
Using transient transfection of a luciferase reporter construct, they determined that a simple upstream repeat is required for normal expression of SNCA. A similar, but not identical, repeat is located in the promoter region of the mouse Snca gene.
How does the SNCA gene affect the risk of PD?
In conclusion, SNPs within the SNCA gene can modify the susceptibility to PD, leading to increased or decreased risk. The risk associations of some SNPs varied among samples. Of notice, no studies in South American or African populations were found.
Where is alpha synuclein found in the human body?
View/Edit Mouse. Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. It is abundant in the brain while smaller amounts are found in the heart, muscles, and other tissues.