How do you treat Aspergillus in dogs?

In dogs, topical treatment is considered the treatment of choice for nasal and paranasal aspergillosis. Several surgical techniques and drug regimens have been used with varying success. Clotrimazole formulated in a polyethylene glycol base is generally considered the first-line treatment.

What antibiotics treat Aspergillus?

These drugs are the standard treatment for invasive pulmonary aspergillosis. The most effective treatment is a newer antifungal drug, voriconazole (Vfend). Amphotericin B is another option.

What drug kills Aspergillus?

Azole-Resistant Aspergillosis Triazole antifungal drugs, commonly called azoles, are the primary treatment for aspergillosis. Azole-resistant A. fumigatus infections are difficult to treat, and these patients are up to 33% more likely to die than patients with infections that can be treated with azoles.

How Long Can dogs live with Aspergillus?

There has been one reported survival of 4.3 years in a dog with disseminated aspergillosis and diskospondylitis treated with itraconazole alone for 2.7 years [9]. This dog was euthanized due to relapse of clinical signs after treatment was discontinued.

Are there any new drugs for aspergillosis in dogs?

Amphotericin B (brand names Abelcet®, AmBisome®, Fungizone®) is an older antifungal drug, largely replaced by newer antifungal drugs due to its high potential to cause kidney damage. Unfortunately, many of these newer drugs are less effective against aspergillosis. To reduce the damaging side effects to the kidneys]

How to treat nasal and paranasal aspergillosis in dogs?

A blood and urine galactomannan antigen assay for diagnosis of systemic aspergillosis in dogs has been described to have moderate sensitivity and specificity. In dogs, topical treatment is considered the treatment of choice for nasal and paranasal aspergillosis. Several surgical techniques and drug regimens have been used with varying success.

How are anti fungals used to treat aspergillosis?

Anti-fungals are not highly effective against aspergillosis, because they fail to get enough active drug into the fungal plaques to kill them. This is because the fungus grows in the skull chambers and the only way for the drug to contact the fungus is via the blood supply to the nose.

How does aspergillosis in dogs cause an infection?

Aspergillosis begins when susceptible dogs inhale mold spores. In some dogs, the spores trigger an allergic reaction. In others, the spores cause an infection. Most infections are localized in the nose (nasal aspergillosis) but some dogs will develop mild to serious lung infections as well.