Guidelines

What is the function of p53?

What is the function of p53?

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

How does overexpression of p53 cause cancer?

Tumor suppressor p53 is reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in inactivation and often an accumulation of the protein in the tumor cells. Only low amounts of protein are detectable in normal tissues.

How is p53 inactivated?

Paired with MDM2, also known as HDM2 in humans, the two proteins completely degrade p53 in a laboratory model. This is a process known as poly-ubiquitination, which means a specific protein completely disappears in a cell. They also did experiments on cancerous human brain tissue and found the same results.

What is p53 NCBI?

p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of different cellular stress signals.

What does p53 do?

The p53 gene is one type of tumor suppressor gene. This gene codes for proteins that function as a safety net, preventing abnormal cells from developing into cancer cells.

Why is p53 important?

p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular organisms to suppress cancer.

What is the function of p53 signaling pathway?

P53-mediated cell signal transduction pathway plays an important role in regulating the normal life activities of cells , and it is involved in the regulation of 160 genes . Apoptosis and senescence are the main pathways by which p53 inhibits tumors. Normal p53 can monitor and identify DNA damage points.

How does p53 affect cell division?

This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA.