What is the pathogenesis of parvovirus?

PATHOGENESIS. CPV is a small, nonenveloped, single-stranded DNA virus that replicates in the nucleus of dividing cells in late the S phase or early G2 phase of the cell cycle. This leads to the preferential infection of rapidly dividing cells, hence the effects of the virus on the bone marrow and the GI tract.

What causes erythema infectiosum?

Erythema infectiosum, often referred to as fifth disease, is caused by human parvovirus B19 and occurs most often during the spring months, often in geographically limited outbreaks among children, particularly school age children.

What is the description of erythema infectiosum?

Erythema infectiosum is a contagious viral infection that causes a blotchy or raised red rash and a slapped-cheek red rash on the face along with mild illness. Erythema infectiosum is caused by a virus. Symptoms include a mild fever, slapped-cheek red rash on the face, and a lacy rash on the arms, legs, and trunk.

What is the causative agent for erythema infectiosum?

—Human parvovirus (B19) is now known to be the causative agent of erythema infectiosum (EI) or “fifth disease.” Erythema infectiosum is characterized by a distinctive facial rash, giving a “slapped cheek” appearance.

When does erythema infectiosum affect an adult?

Viruses with specific effects on neonates are discussed in Infections in Neonates. This chapter covers viral infections that are typically acquired during childhood (although many may also affect adults). Erythema infectiosum, often referred to as fifth disease, is caused by human parvovirus B19.

Can a pregnant woman get erythema infectiosum?

Erythema infectiosum can be transmitted transplacentally, sometimes resulting in stillbirth or severe fetal anemia with widespread edema (hydrops fetalis). However, about half of pregnant women are immune because of previous infection.

What kind of joint pain does erythema infectiosum cause?

Mild joint pain and swelling (nonerosive arthritis) that may persist or recur for weeks to months sometimes occurs in adults.