What is electrophilic aromatic substitution give example?

Nitration and Sulfonation. Nitration and sulfonation of benzene are two examples of electrophilic aromatic substitution. The nitronium ion (NO2+) and sulfur trioxide (SO3) are the electrophiles and individually react with benzene to give nitrobenzene and benzenesulfonic acid respectively.

What are electrophilic aromatic substitution reactions used for?

Electrophilic aromatic substitution is one of the most important reactions in synthetic organic chemistry. Such reactions are used for the synthesis of important intermediates that can be used as precursors for the production of pharmaceutical , agrochemical and industrial products.

Which of the following is an example of electrophilic substitution?

substitution reaction This reaction is known as electrophilic substitution. Examples of electrophilic species are the hydronium ion (H3O+), the hydrogen halides (HCl, HBr, HI), the nitronium ion (NO2+), and sulfur trioxide (SO3).

What is electrophilic aromatic substitution in benzene?

What is Electrophilic Substitution of Benzene? Electrophilic substitution of benzene is the one where an electrophile substitutes the hydrogen atom of benzene. Basic examples of electrophilic substitution reaction of benzene are nitration, sulfonation, halogenation, Friedel Craft’s alkylation and acylation, etc.

How is the aromaticity preserved in an electrophilic substitution reaction?

Commonly, these reactions involve the replacement of a hydrogen atom belonging to a benzene ring with an electrophile. The aromaticity of the aromatic system is preserved in an electrophilic aromatic substitution reaction.

How is electrophilic aromatic substitution used to treat depression?

a proton pump inhibitor used to treat acid reflux HN Cl Cl Zoloft used for treating depression Experiment 16 – Electrophilic Aromatic Substitution Page 2 of 8 second part of the mechanism involves reaction of the benzene p-bond with either the Lewis acid-base adduct (shown) or simply with Br⊕to provide a carbocation intermediate.

What are the different types of aromatic substitution reactions?

There exist many types of electrophilic aromatic substitution reactions, the most important of which include: Aromatic nitration reactions. Electrophilic aromatic halogenation reactions. Aromatic sulfonation reactions. Friedel-Crafts alkylation reaction.

How is bromide used in an electrophilic substitution?

Bromide (Br⊖), from FeBr 4－then acts as a base removing a proton from the ring to form a p-bond and reestablishing aromaticity. This overall process is referred to as an electrophilic aromatic substitution (EAS) because a hydrogen on the aromatic ring is substituted with an electrophile, such as Br. (Figure 3) Figure 3.