What is dimethyl sulfate used for?

The major use of dimethyl sulfate is as an alkylating agent. It is used in the manufacture of dyes, pharmaceuticals and perfumes and in the extraction of aromatic hydrocarbons as a solvent. It is also used as a sulfating and sulfonating agent. In World War I, it was used as a war gas.

How does dimethyl sulfate decompose?

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. It is very toxic by inhalation. It is a combustible liquid and has a flash point of 182°F. It is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat.

What is the role of dimethyl sulphate in preparation of Nerolin?

Dimethyl sulphate (CH3)2SO4 (DMS) is a methylating agent used industrially in the synthesis of pharmaceuticals, dyestuffs, perfumes, and pesticides. It is also used medically for chemical cleavage of DNA sequences. DMS is highly toxic, corrosive, and has carcinogenic, mutagenic, and teratogenic potential.

How is dimethyl sulfate determined in gas chromatography?

During a routine determination of dimethyl sulfate in technical materials using gas chromatography-mass spectrometry (GC-MS), we found that residual monomethyl sulfate originating from a prior methylation reaction with dimethyl sulfate decomposed in the hot GC injection system to yield dimethyl sulfate and sulfuric acid.

Why is dimethyl sulfate used in the API process?

Dimethyl sulfate (DMS) is an alkylating reagent commonly used in organic syntheses and pharmaceutical manufacturing processes. Due to its potential carcinogenicity, the level of DMS in the API process needs to be carefully monitored. However, in-process testing for DMS is challenging because of its …

How to make dimethyl sulfate with diethyl ether?

DIMETHYL SULFATE: METHOD 2524, Issue 2, dated 15 August 1994 – Page 2 of 4 REAGENTS: 1. Dimethyl sulfate, 99%.* 2. Diethyl ether,* anhydrous, preserved with ethanol. 3. Calibration stock solution, 12 µg/µL. Add 120 mg (90 µL) dimethyl sulfate to a pre-weighed 10-mL volumetric flask. Re-weigh and dilute to the mark with diethyl ether. 4.

How to determine the presence of monomethyl sulfate?

This short communication describes proper measures to counteract this problem and presents a fast, reliable and validated GC-MS method that is capable of determining dimethyl sulfate residues in the presence of monomethyl sulfate in technical materials using a simple dissolve-and-inject approach.