Articles

How does LDL become oxidized?

How does LDL become oxidized?

The oxidation of LDL is thought to occur when LDL cholesterol particles in your body react with free radicals; unstable molecules that are produced as a result of normal metabolism, a disease, or exposure to toxins. LDL cholesterol molecules are not all the same size, and some are larger than others.

What does it mean for LDL to be oxidized?

Oxidized LDL is LDL cholesterol (the “bad” cholesterol) that has been modified by oxidation. Oxidized LDL triggers inflammation leading to the formation of plaque in the arteries, also known as atherosclerosis.

Can you measure oxidized LDL?

If you have high cholesterol or high blood pressure, your doctor can test you to see if you have a high level of oxidized LDL in your body. A routine lipid profile blood test can give you total cholesterol results, but it doesn’t test for oxidized cholesterol.

What is the difference between LDL and oxidized LDL?

Low density lipoprotein (LDL) can be oxidized in a stepwise process that leads to the production of minimally modified low density lipoprotein (mm-LDL), in which only the lipid component is oxidized, and then of fully oxidized LDL (oxLDL), in which both the lipids and the protein are oxidized.

Is the cholesterol hypothesis true for heart disease?

Since there has been such widespread agreement that the cholesterol hypothesis is true, and that drugs that lower LDL also lower heart disease, cardiologists’ organizations around the world have set targets for LDL levels in the blood stream.

What happens to LDL cholesterol when it is oxidized?

Oxidized LDL, or oxLDL, is a type of low-density lipoprotein (known as LDL cholesterol) that has become damaged by a chemical reaction with harmful molecules known as free radicals. How does oxLDL occur? As LDLs encounter free radicals, the two compounds combine through a chemical process known as oxidation and form oxidized LDL cholesterol.

Is the low fat diet the heart hypothesis?

The low-fat “diet–heart hypothesis” has been controversial for nearly 100 years.

Is there a link between LDL cholesterol and heart disease?

LDL cholesterol levels and LDL particle number are often concordant (i.e. when one is high, the other is high, and vice versa), and this is probably why there is an association between LDL cholesterol and heart disease in observational studies. The elevated LDL cholesterol was more of a proxy marker for elevated LDL particle number in these cases.