How do you treat PJI?

In the United States, chronic PJI has been mainly treated via two-stage exchange arthroplasty with a 4 to 8 week course of IV antibiotics in between the two stages.

What is prosthetic infection?

Prosthetic joint infection (PJI), also referred to as periprosthetic infection, is defined as infection involving the joint prosthesis and adjacent tissue.

What is Dair procedure?

Debridement Antibiotics and Implant Retention(DAIR) is a procedure to treat a periprosthetic joint infection(PJI) after Total Hip Arthroplasty(THA) or Total Knee Arthroplasty(TKA). The timing between the primary procedure and the DAIR is likely a determinant for its successful outcome.

What is acute PJI?

For the acute period (within less than 6 weeks postoperatively), a threshold of > 10,000 cells per microliter for the synovial WBC count as well as a threshold of > 90% for synovial PMN % is recommended to diagnose PJI [34].

What is the meaning of septic arthritis?

Septic arthritis is an infection in the joint (synovial) fluid and joint tissues. It occurs more often in children than in adults. The infection usually reaches the joints through the bloodstream. In some cases, joints may become infected due to an injection, surgery, or injury.

How do doctors replace damaged bones in joints such as knees or hips?

Total joint replacement is a surgical procedure in which parts of an arthritic or damaged joint are removed and replaced with a metal, plastic, or ceramic device called a prosthesis. The prosthesis is designed to replicate the movement of a normal, healthy joint.

Why do prosthetics get infected?

Most prosthetic joint infections are the result of bacteria—often Staphylococcus aureus—present in the body or introduced during the surgery itself or subsequent procedures.

Can a prosthetic get infected?

Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection.

What is debridement antibiotics and implant retention?

Debridement, antibiotics, and implant retention (DAIR) is an attractive option for treating prosthetic joint infection (PJI). DAIR has demonstrated reduced morbidity and superior functional outcomes when compared to one- or two-stage revision by minimizing bone loss and soft tissue trauma [1,2].

What is a Synovasure test?

The Synovasure Lateral Flow Test Kit detects proteins called human alpha defensins in the synovial fluid of patients with a total joint replacement in approximately 10 minutes. Alpha defensins are antimicrobial proteins released by activated neutrophils (white blood cells) in response to infection.

What is meant by arthroplasty?

Arthroplasty is a surgical procedure to restore the function of a joint. A joint can be restored by resurfacing the bones. An artificial joint (called a prosthesis) may also be used. Various types of arthritis may affect the joints.

How did I get septic arthritis?

Septic arthritis can develop when an infection, such as a skin infection or urinary tract infection, spreads through your bloodstream to a joint. Less commonly, a puncture wound, drug injection, or surgery in or near a joint — including joint replacement surgery — can give the germs entry into the joint space.