What does Myocytolysis mean?

Myocytolysis refers to a state of significant damage to cardiac myocytes, muscle cells of the heart, caused by myocardial strain.

What causes contraction bands?

Contraction band necrosis is thought to arise by two mechanisms: a calcium-dependent mechanism – activation of the contractile machinery of the cell via its usual mechanism, calcium, which is in excess due to ischemia.

What is myocyte necrosis?

Cardiac Myocyte Death in the Pathogenesis of Disease Cell death, either progressive or acute, is a hallmark characteristic of various cardiac diseases, including heart failure (HF), myocardial infarction (MI), and ischemia/reperfusion (I/R; Figure 1).

What is Reperfuse?

Reperfusion: The restoration of blood flow to an organ or to tissue. After a heart attack, an immediate goal is to quickly open blocked arteries and reperfuse the heart muscles.

What happens to the wall of the heart in obstructive HCM?

In obstructive HCM, the wall (septum) between the two bottom chambers of the heart thickens. The walls of the pumping chamber can also become stiff.

What does obstructive hypertrophic cardiomyopathy do to heart?

If this happens, the condition is called obstructive hypertrophic cardiomyopathy. Sometimes the septum, the wall that divides the left and right sides of the heart, thickens and bulges into the left ventricle. This can block blood flow out of the left ventricle. Then the ventricle must work hard to pump blood.

How does hypertrophic cardiomyopathy affect the mitral valve?

Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy also can affect the heart’s mitral valve, causing blood to leak backward through the valve. Sometimes, the thickened heart muscle doesn’t block blood flow out of the left ventricle. This is referred to as non-obstructive hypertrophic cardiomyopathy.

What are the complications of left ventricular hypertrophy?

As a result of these changes, complications of left ventricular hypertrophy include: 1 Reduced blood supply to the heart. 2 Inability of the heart to pump enough blood to your body (heart failure). 3 Abnormal heart rhythm (arrhythmia). 4 Irregular, often rapid heartbeat (atrial fibrillation) that decreases blood flow to the body.